GLP-1 Agonist Comparison: Semaglutide vs Tirzepatide vs Liraglutide

GLP-1 receptor agonists have revolutionized weight management, but choosing between options can be confusing. This comprehensive comparison helps you understand the differences.

Quick Comparison Overview

At-a-Glance Comparison

FactorSemaglutideTirzepatideLiraglutide Brand NamesOzempic, WegovyMounjaro, ZepboundSaxenda, Victoza MechanismGLP-1 onlyGLP-1 + GIPGLP-1 only FrequencyWeeklyWeeklyDaily Max Weight Loss~15-17%~20-22%~8-10% Approval2021 (obesity)2023 (obesity)2014 (obesity)

Detailed Medication Profiles

Semaglutide (Ozempic/Wegovy)

Clinical Results:
• Average weight loss: 15-17%
• 35% of users lose 20%+ body weight
• Significant cardiovascular benefits

Pros:
• Extensive research and safety data
• Once-weekly convenience
• Cardiovascular benefits proven
• Available as oral form (Rybelsus)

Cons:
• GI side effects common initially
• Supply shortages occurred
• Insurance coverage variable

Tirzepatide (Mounjaro/Zepbound)

Clinical Results:
• Average weight loss: 20-22%
• 57% of users on max dose lose 20%+ body weight
• Superior to semaglutide in head-to-head studies

Pros:
• Highest weight loss of any medication
• Dual mechanism (GLP-1 + GIP)
• Once-weekly dosing
• Excellent glycemic control

Cons:
• Newest option (less long-term data)
• Similar GI side effects
• Highest cost

Liraglutide (Saxenda/Victoza)

Clinical Results:
• Average weight loss: 8-10%
• Established long-term safety profile
• Well-studied in diverse populations

Pros:
• Longest track record
• Most safety data available
• May suit those who need dose flexibility
• More affordable than newer options

Cons:
• Daily injections required
• Lower weight loss than newer options
• More frequent dosing = more injections

Choosing the Right Option

Choose Semaglutide If:

You want proven, well-studied option

Cardiovascular health is priority

You prefer established safety profile

Insurance covers Wegovy

You want oral option available

Choose Tirzepatide If:

Maximum weight loss is priority

You haven't responded well to semaglutide

You have significant weight to lose

Type 2 diabetes is present

You want the most effective option

Choose Liraglutide If:

Cost is a significant factor

You prefer shorter dose escalation

You're comfortable with daily injections

Moderate weight loss is acceptable

Side Effect Comparison

Gastrointestinal Side Effects: Side EffectSemaglutideTirzepatideLiraglutide

Nausea44%31%39% Diarrhea31%23%21% Vomiting24%12%16% Constipation24%17%19%

Cost Comparison

Monthly Cost Estimates (2024)

MedicationWithout InsuranceWith Insurance Semaglutide (Wegovy)$1,200-1,400$0-500 Tirzepatide (Zepbound)$1,000-1,300$0-500 Liraglutide (Saxenda)$1,000-1,300$0-400 Compounded versions$150-500N/A

Conclusion

Summary Recommendations

For Maximum Weight Loss: Tirzepatide For Proven Safety Profile: Semaglutide For Lower Cost: Liraglutide or compounded options For Cardiovascular Benefits: Semaglutide

Work with your healthcare provider to determine the best GLP-1 option for your individual situation, health goals, and circumstances.