NAD+ for Anti-Aging: How This Molecule Can Slow Down Aging

NAD+ (Nicotinamide Adenine Dinucleotide) has emerged as one of the most promising molecules in anti-aging research. This guide explores how NAD+ works, its benefits, and how you can optimize your NAD+ levels.

What is NAD+?

NAD+ is a coenzyme found in every cell of your body. It plays essential roles in:

Energy production - Critical for converting food into cellular energy (ATP)

DNA repair - Helps repair damaged DNA

Cell signaling - Regulates cellular communication

Gene expression - Influences which genes are turned on or off

Circadian rhythm - Helps regulate your body clock

Why NAD+ Declines with Age

Research shows NAD+ levels decline significantly as we age:

By age 50, NAD+ levels are approximately 50% of what they were at age 20

By age 80, NAD+ levels may be only 1-10% of youthful levels

This decline is linked to:
• Increased DNA damage
• Chronic inflammation
• Oxidative stress
• Decreased mitochondrial function

NAD+ and the Aging Process

Sirtuin Activation

NAD+ is essential for activating sirtuins, a family of proteins often called "longevity genes." Sirtuins regulate:

Cellular metabolism

DNA repair

Inflammation

Stress resistance

Lifespan in animal studies

Mitochondrial Function

Mitochondria are the powerhouses of your cells. NAD+ is crucial for:

Electron transport chain function

ATP production

Mitochondrial biogenesis

Prevention of mitochondrial dysfunction

DNA Repair (PARP Enzymes)

PARP enzymes use NAD+ to repair DNA damage. With declining NAD+ levels:

DNA damage accumulates

Cellular function deteriorates

Aging accelerates

Benefits of NAD+ Supplementation

1. Increased Energy

NAD+ supports mitochondrial function, leading to:

More cellular energy (ATP)

Reduced fatigue

Improved physical performance

Better exercise recovery

2. Enhanced Cognitive Function

NAD+ may support brain health through:

Improved neuronal function

Reduced neuroinflammation

Enhanced memory and focus

Protection against neurodegeneration

3. Metabolic Health

NAD+ influences metabolism by:

Improving insulin sensitivity

Supporting healthy glucose levels

Enhancing fat metabolism

Promoting metabolic flexibility

4. Cellular Repair

With adequate NAD+:

DNA repair mechanisms function optimally

Damaged cells are cleared more efficiently

Cellular senescence is reduced

Tissue regeneration improves

5. Cardiovascular Support

Research suggests NAD+ may help:

Maintain healthy blood vessels

Support heart function

Reduce oxidative damage to the cardiovascular system

NAD+ Supplementation Options

1. NAD+ IV Therapy

Pros:

100% bioavailability

Immediate effects

High-dose delivery possible

Cons:
• Requires clinic visit
• Higher cost
• Can cause flushing during infusion

Typical Protocol:
• 250-1000mg per session
• Sessions last 2-4 hours
• Weekly to monthly frequency

2. NAD+ Injections

Pros:

High bioavailability (subcutaneous or IM)

Can be done at home

More affordable than IV

Cons:
• Requires injection
• Lower doses than IV typically

Available Doses:
• NAD+ 100mg - Beginner/maintenance
• NAD+ 200mg - Standard anti-aging
• NAD+ 500mg - High-potency therapy

3. NAD+ Precursors (Oral)

NMN (Nicotinamide Mononucleotide):

Converts directly to NAD+

Good absorption when taken sublingually

Typical dose: 250-500mg daily

NR (Nicotinamide Riboside):
• Must convert to NMN, then NAD+
• Well-studied in humans
• Typical dose: 300-600mg daily

Niacin (Vitamin B3):
• Oldest NAD+ precursor
• Can cause flushing
• Typical dose: 500-1000mg daily

NAD+ Dosage Guidelines

For Maintenance

NAD+ injection: 100-200mg weekly

NMN oral: 250-500mg daily

NR oral: 300-500mg daily

For Anti-Aging Protocol

NAD+ injection: 200-500mg 2-3x weekly

NMN oral: 500-1000mg daily

NR oral: 500-1000mg daily

For Intensive Therapy

NAD+ IV: 500-1000mg weekly

NAD+ injection: 500mg 3x weekly

Often combined with other therapies

How to Naturally Boost NAD+

Diet

Dairy products - Contain NAD+ precursors

Fish - Rich in niacin

Chicken - Good source of niacin

Green vegetables - Support NAD+ metabolism

Fermented foods - Contain NAD+ precursors

Lifestyle

Exercise - Increases NAD+ levels naturally

Fasting - Caloric restriction boosts NAD+

Quality sleep - Supports circadian NAD+ rhythm

Reduce alcohol - Alcohol depletes NAD+

Avoid overeating - Excess calories lower NAD+

Supplements That Support NAD+

Resveratrol - Activates sirtuins

Quercetin - Inhibits CD38 (NAD+ consumer)

Apigenin - May preserve NAD+ levels

Pterostilbene - Similar to resveratrol

Combining NAD+ with Other Therapies

NAD+ + Glutathione

This combination offers:

Enhanced detoxification

Greater antioxidant protection

Synergistic anti-aging benefits

Improved skin health

NAD+ + Vitamin C

Benefits include:

Enhanced immune function

Better collagen synthesis

Increased antioxidant capacity

Improved energy levels

Side Effects and Safety

NAD+ is generally well-tolerated. Possible side effects include:

During IV Infusion:
• Flushing
• Nausea
• Headache
• Chest pressure (resolve when infusion slows)

With Injections:
• Injection site reaction
• Mild nausea
• Headache (rare)

Precautions:
• Start with lower doses
• Consult healthcare provider if you have medical conditions
• Monitor for any unusual reactions

The Future of NAD+ Research

Ongoing research is exploring NAD+ for:
• Neurodegenerative diseases (Alzheimer's, Parkinson's)
• Heart disease prevention
• Cancer metabolism
• Age-related hearing loss
• Muscle aging and sarcopenia

Getting Started with NAD+

1. Assess your goals - Maintenance vs. intensive therapy 2. Choose your method - IV, injection, or oral precursors 3. Start low - Begin with lower doses 4. Be consistent - NAD+ benefits build over time 5. Track your progress - Note energy, cognition, and overall well-being 6. Combine with healthy lifestyle - Diet and exercise enhance results

Conclusion

NAD+ supplementation represents one of the most promising approaches to supporting healthy aging at the cellular level. Whether through IV therapy, injections, or oral precursors, boosting NAD+ levels may help maintain energy, support cognitive function, and promote overall cellular health.

Explore our NAD+ products to begin your cellular rejuvenation journey.