NAD+ Dosage Guide: 100mg vs 200mg vs 500mg - Which is Right for You?

Choosing the right NAD+ dosage is crucial for achieving your health and anti-aging goals. This comprehensive guide breaks down the differences between common NAD+ doses and helps you create an effective protocol.

Understanding NAD+ Dosing

NAD+ supplementation differs from many supplements because:
• It directly enters metabolic pathways
• Effects are dose-dependent
• Individual needs vary significantly
• Administration method affects optimal dose

NAD+ Dose Comparison

NAD+ 100mg

Overview: Entry-level dose suitable for maintenance and beginners

Best For:
• First-time NAD+ users
• Ongoing maintenance after loading
• Those with budget constraints
• Younger individuals (under 40)
• General wellness support

Expected Benefits:
• Mild energy improvement
• Baseline cellular support
• Maintaining existing NAD+ levels
• Subtle cognitive enhancement

Typical Protocol:
• 2-3 times per week for maintenance
• Can be combined with precursors (NMN/NR)
• Good for prevention rather than restoration

NAD+ 200mg

Overview: Standard dose for most anti-aging and therapeutic purposes

Best For:
• Active anti-aging protocol
• Moderate energy needs
• Adults 40-60 years old
• Recovery from illness or fatigue
• Cognitive enhancement focus

Expected Benefits:
• Noticeable energy increase
• Improved mental clarity
• Better exercise recovery
• Visible anti-aging effects
• Enhanced mood stability

Typical Protocol:
• 2-3 times per week during loading
• Weekly for maintenance
• Popular middle-ground option

NAD+ 500mg

Overview: High-potency dose for intensive therapy

Best For:
• Significant NAD+ depletion
• Advanced age (60+)
• Recovery from addiction
• Chronic fatigue conditions
• Intensive biohacking protocols
• Professional/clinical settings

Expected Benefits:
• Maximum cellular restoration
• Significant energy boost
• Intensive cognitive support
• Rapid NAD+ level restoration
• Comprehensive anti-aging effects

Typical Protocol:
• 2-3 times per week for short periods
• Transition to lower doses for maintenance
• Professional supervision recommended

Dosing Protocols by Goal

Protocol 1: General Wellness (Preventive)

Goal: Maintain healthy NAD+ levels Dose: 100mg Frequency: 2-3 times weekly Duration: Ongoing

Protocol 2: Anti-Aging (Standard)

Goal: Combat age-related NAD+ decline Dose: 200mg Schedule:

Loading: 2x weekly for 4 weeks

Maintenance: Weekly ongoing

Protocol 3: Energy Enhancement

Goal: Combat fatigue and boost energy Dose: 200-500mg Schedule:

Intensive: 500mg 2x weekly for 2 weeks

Maintenance: 200mg weekly

Protocol 4: Cognitive Enhancement

Goal: Mental clarity and brain health Dose: 200mg Schedule:

Initial: 2-3x weekly for 4 weeks

Maintenance: 1-2x weekly ongoing

Protocol 5: Recovery/Restoration (Intensive)

Goal: Rapid NAD+ replenishment Dose: 500mg Schedule:

Intensive: 3x weekly for 2-3 weeks

Transition: 200mg 2x weekly for 4 weeks

Maintenance: 200mg weekly or 100mg 2x weekly

Factors Affecting Optimal Dose

Age

Under 40: 100-200mg often sufficient

40-60: 200mg typical starting point

Over 60: 200-500mg may be needed

Health Status

Generally healthy: Lower doses

Chronic conditions: May need higher doses

Recovering from illness: Higher initial doses

Lifestyle

High stress: May need higher doses

Alcohol consumption: Increases NAD+ needs

Poor sleep: May benefit from higher doses

Regular exercise: Moderate doses sufficient

Goals

Maintenance: 100mg

Active anti-aging: 200mg

Intensive therapy: 500mg

Administration Methods

Subcutaneous Injection

Most common self-administered method

Good absorption (estimated 80-90%)

Can be done at home

Slight discomfort possible

Best For: 100-200mg doses

Intramuscular Injection

Slightly faster absorption

Can handle larger volumes

More discomfort than SubQ

Best For: 200-500mg doses

Intravenous (IV) Drip

100% bioavailability

Requires clinical setting

Can deliver highest doses

Session takes 1-4 hours

Best For: 500mg+ intensive protocols

IV Push

Faster than drip

Still requires professional

Quick administration

Best For: Moderate to high doses in clinical settings

Creating Your Protocol

Step 1: Assess Your Starting Point

Consider:

Current age

Energy levels

Health conditions

Previous NAD+ experience

Step 2: Define Your Goals

General wellness?

Anti-aging?

Energy boost?

Cognitive enhancement?

Recovery?

Step 3: Choose Starting Dose

SituationRecommended Start Under 40, healthy100mg 40-60, preventive100-200mg 40-60, therapeutic200mg Over 60200-500mg Recovery/intensive500mg

Step 4: Plan Your Schedule

Loading Phase (4-6 weeks):

More frequent injections (2-3x weekly)

Establish baseline benefits

Maintenance Phase (ongoing):
• Reduced frequency (weekly or bi-weekly)
• Maintain achieved benefits

Step 5: Monitor and Adjust

Track:

Energy levels

Mental clarity

Sleep quality

Overall wellbeing

Any side effects

Adjust dose/frequency based on response.

Combining NAD+ with Other Treatments

NAD+ + Glutathione

Protocol:

NAD+ 200mg + Glutathione 600mg

Same injection or separate

Enhanced antioxidant and anti-aging benefits

NAD+ + Vitamin B Complex

Protocol:

NAD+ 100-200mg

B-complex supplement (oral)

Supports NAD+ metabolism

NAD+ + NMN/NR (Oral)

Protocol:

Lower NAD+ injection dose (100mg)

NMN 250-500mg daily (oral)

Cost-effective combination approach

Side Effects by Dose

100mg

Generally very well tolerated

Minimal side effects

Slight injection site reaction possible

200mg

Well tolerated by most

Mild flushing possible

Occasional headache

Slight nausea rare

500mg

More noticeable effects

Flushing more common

Temporary chest tightness possible

Nausea may occur

Headache possible

Should slow administration if effects occur

Tips for Best Results

Before Injection

Stay hydrated

Eat a light meal

Prepare clean workspace

Have supplies ready

During Administration

Inject slowly

Rotate injection sites

Note any reactions

After Injection

Stay hydrated

Avoid alcohol

Light activity is fine

Note energy levels

Ongoing

Be consistent with schedule

Track your progress

Adjust based on results

Consider periodic breaks

Cost Considerations

DoseCost per InjectionMonthly Cost (2x weekly) 100mg$$$$ 200mg$$$$$$ 500mg$$$$$$$$

Cost-Saving Tips:
• Start with lower dose, increase if needed
• Combine with oral precursors
• Use loading phases followed by maintenance
• Buy in bulk when possible

Frequently Asked Questions

Q: Can I take too much NAD+? A: While generally safe, very high doses may cause discomfort. Start low and increase gradually.

Q: How quickly will I feel effects? A: Some notice effects within days, others take weeks. 500mg may provide faster initial response.

Q: Should I cycle NAD+? A: Some protocols include breaks. Discuss with your provider.

Q: Can I split a 500mg dose? A: Yes, some prefer 250mg twice weekly instead of 500mg once.

Q: Is more always better? A: No. Find the minimum effective dose for your goals.

Conclusion

Choosing the right NAD+ dose depends on your age, health status, and goals. Start conservatively and adjust based on your response. Remember that consistency is key - regular, moderate doses often outperform sporadic high doses.

Explore our range of NAD+ products at 100mg, 200mg, and 500mg to find the right option for your anti-aging protocol.